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(Antioksidacijski učinci flavonoida iz hrvatske pčelinje peludi bogate bušincom)

Sarić A, Balog T, Sobocanec S, Kusić B, Sverko V, Rusak G, Likić S, Bubalo D, Pinto B, Reali D, Marotti T.

Division of Molecular Medicine, Rudjer Bosković Institute, Bijenicka 54, 10000 Zagreb, Croatia.

Oxidant/antioxidant status, estrogenic/anti-estrogenic activity and gene expression profile were studied in mice fed with Cystus incanus L. (Cistaceae) reach bee pollen from location in Central Croatia’s Dalmatia coast and offshore islands. Seven phenolic compounds (out of 13 tested) in bee pollen sample were detected by high performance liquid chromatography (HPLC) analysis. Phenolics detected in C. incanus L. bee pollen belong to flavonol (pinocembrin), flavanols (quercetin, kaempferol, galangin, and isorhamnetin), flavones (chrysin) and phenylpropanoids (caffeic acid). Bee pollen as a food supplement (100mg/kgbw mixed with commercial food pellets) compared to control (commercial food pellets) modulated antioxidant enzymes (AOE) in the mice liver, brain and lysate of erythrocytes and reduced hepatic lipid peroxidation (LPO). Bee pollen induced 25% of anti-estrogenic properties while no estrogenic activity was found. Differential gene expression profile analyses after bee pollen enriched diet identify underexpressed gene Hspa9a, Tnfsf6 (liver) and down-regulated gene expression of Casp 1 and Cc121c (brain) which are important in the apoptosis pathway and chemotaxis. These results indicate that used bee pollen possess a noticable source of compounds with health protective potential and antioxidant activity.
Food Chem Toxicol. 2009 Mar;47(3):547-54. Epub 2008 Dec 16.

Sarić A, Balog T, Sobocanec S, Kusić B, Sverko V, Rusak G, Likić S, Bubalo D, Pinto B, Reali D, Marotti T.
Division of Molecular Medicine, Rudjer Bosković Institute, Bijenicka 54, 10000 Zagreb, Croatia.

Oxidant/antioxidant status, estrogenic/anti-estrogenic activity and gene expression profile were studied in mice fed with Cystus incanus L. (Cistaceae) reach bee pollen from location in Central Croatia’s Dalmatia coast and offshore islands. Seven phenolic compounds (out of 13 tested) in bee pollen sample were detected by high performance liquid chromatography (HPLC) analysis. Phenolics detected in C. incanus L. bee pollen belong to flavonol (pinocembrin), flavanols (quercetin, kaempferol, galangin, and isorhamnetin), flavones (chrysin) and phenylpropanoids (caffeic acid). Bee pollen as a food supplement (100mg/kgbw mixed with commercial food pellets) compared to control (commercial food pellets) modulated antioxidant enzymes (AOE) in the mice liver, brain and lysate of erythrocytes and reduced hepatic lipid peroxidation (LPO). Bee pollen induced 25% of anti-estrogenic properties while no estrogenic activity was found. Differential gene expression profile analyses after bee pollen enriched diet identify underexpressed gene Hspa9a, Tnfsf6 (liver) and down-regulated gene expression of Casp 1 and Cc121c (brain) which are important in the apoptosis pathway and chemotaxis. These results indicate that used bee pollen possess a noticable source of compounds with health protective potential and antioxidant activity.
Food Chem Toxicol. 2009 Mar;47(3):547-54. Epub 2008 Dec 16.

Natural source of vitamines and minerals

Bee pollen with propolis® is the natural mineral-vitamin mixture which contains the original unprocessed bee pollen dominated by the pollen from Dalmatian plant Rock Rose (Cistus sp.). Pollen is a male reproductive cell of plant which contains not only vitamins and minerals but many other substances necessary for the creation, development and maintenance of life. Unlike other similar synthetic preparations, natural ingredients from the pollen easily and quickly transferred from the digestive system in systemic circulation and have no harmful effects.

The product is GLUTEN FREE.

Content
1 hydroxypropylmethyl cellulose capsule contains 400 mg of bee pollen stabilized with 50 mg of propolis.

Usage 
Additional minerals and vitamins are necessary for people that are not eating regularly or if they are often under stress, take pleasure in alcohol, smoking or are on a diet. It is particularly advised for the elderly, pregnant women, nursing women, people in rehabilitation process and the ones with heighten physical activities (athletes, business people) and people with chronic diseases who are continually taking medications.

Dosage and administration
2x2 capsules per day are used as prevention, half an hour before meal or in between meals. In special conditions (recovering after diseases, heighten physical activity, low calorie diet) dose can be increased from 2x3 capsules per day.

Adverse effects
There are no harmful effects or possibility to overdose with pollen.

Precautions
People allergic to bee products are recommended not to use it.

Packaging
Bottle contains 60 capsules.

Shelf life
1,5 years

The basis of the strategic development is the project APICEUTICS based on technological development and production of bee products with scientifically proven healing properties, without any chemical processing. Project APICEUTICS has emerged as a product of the Ministry of Science and Education for knowledge-based companies. Relying primarily on the huge domestic potential, Hedera works with 300-plus Croatian beekeepers.
The long term goal of our company is to make available our unique, natural products to users worldwide. Thanks to continuous research and development, the company now has a respectable scientific potential that guarantees success for the company, as well as the quality of the end user.