vitamin e

Zaštita i poboljšanje rada prostate

Naruči ovaj proizvod

Prirodni pripravak APICET sadrži pčelinji cvjetni prah u kojemu dominira pelud dalmatinske biljke bušinac (Cistus monspeliensis). Pelud bušinca se tradicionalno zbog ljekovitih svojstava puno više cijeni od cvjetnog praha ostalih biljaka. Istraživanja sastava i bioaktivnog učinka cvjetnog praha bušinca provedena su u “Institutu Ruđer” Bošković u Zagrebu i Institutu pomorske medicine u Splitu.

SASTAV: 1 želatinozna kapsula sadrži 450 mg pčelinjeg cvjetnog praha

SVOJSTVA I DJELOVANJE: Osim prirodnih vitamina, minerala, ugljikohidrata, lipida i bjelančevina, APICET sadrži i biološki aktivne tvari polifenole (kavena kiselina, galangin, izoramnetin, kemferol, kvercetin, krizin, pinocembrin) koji mu daju ljekoviti učinak. Štiti jetru od oksidacije i nakupljanja slobodnih radikala te joj pomaže u razgradnji štetnih tvari.

Klinička istraživanja ukazuju da pelud spriječava probleme povećane prostate, posebno kod kroničnog prostatitisa (učestala otežana mokrenja s tankim i isprekidanim mlazom, bolovi u donjem dijelu trbuha i leđa, umor, zastoj mokraće, peckanje, bolna ejakulacija, učestale infekcije mokraćnih puteva).

Zdravlju prostate, osim polifenola, doprinose mineral cink te vitamini B6 i E koje sadrži pelud bušinca. Dokazano je da vitamin E smanjuje rizik od raka prostate. Cvjetni prah povoljno djeluje na seksualno zdravlje kod muškaraca (potentnost, plodnost).

UPOTREBA: Upotrebljava se za ublažavanje simptoma uvećane prostate, akutnog nebakterijskog i kroničnog prostatitisa.

DOZIRANJE: Koristi 2x3 kapsule na dan pola sata prije jela ili između obroka.

ŠTETNE POJAVE: Nema štetnih učinaka niti opasnosti od predoziranja peludom.

NAPOMENA: Osobe alergične na pčelinje proizvode ne smiju ga koristiti.

PAKIRANJE: Bočica sadrži 60 kapsula

TRAJNOST: 24 mjeseci

PROIZVOĐAČ: HEDERA d.o.o., Put Vrbovnika bb, 21311 Stobreč, Hrvatska

Antioxidative activity of propolis from Dalmatia (Croatia)

Katalinić V, Radić S, Ropac D, Mulić R, Katalinić A.

Odjel sanitarne kemije i toksikologije, Institut pomorske medicine HRM, Split, Hrvatska.

AIM: The aim of this study was to determine the antioxidative activity of propolis from ecologically clean parts of Dalmatia.

METHODS: Phenol concentration in ethanolic propolis extracts was determined by Folin-Ciocalteu reagent using gallic acid as the standard. Flavonoid phenolic compounds were analyzed after precipitation with formaldehyde. The residual non-flavonoid phenolics were also determined by Folin-Ciocalteu method. By determining the change of peroxide number (PN), of tiobarbiture acid reactive species (TBARS), and of DPPH-radical activity, antioxidative efficiency of propolis was tested and compared with well known and widely used synthetic antioxidants. Values of PN and TBARS were determined at 60 degrees C in samples of trigyceride substrate (lard) without and with the addition of antioxidants. Compared was the efficiency of three antioxidants: propolis (alcoholic extract), vitamin E, and (+)-catechin in a concentration of 1%. PN was monitored during 50 days. By the method of Sedlacek, TBARS were measured during 30 days. Antioxidative activity of propolis extract was also measured in terms of hydrogen donating ability using stable radical alpha,alpha-diphenyl-beta-picril hidrazyl (DPPH*) and compared with commercial synthetic antioxidants of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and (+)-cathecin. Inhibition degree of DPPH* was calculated by the formula of Yen and Duh.

RESULTS: Total phenol content, expressed as gallic acid, in propolis extracts varied from 75.2 to 90.2 g/kg propolis. The proportion of flavonoids in total phenols ranged from 62% to 65%. Values of TBARS were not increased only in samples with added propolis. The inhibition of DPPH-radical by propolis extracts ranged from 93% to 96%, by catechin 95%, by BHT 49%, and by BHA 64%. Compared to BHT and BHA, propolis extracts showed greater reducing activity against DPPH-radical.

DISCUSSION: The chemical composition of propolis, and thus its biological activity depend on the plant from which it has been collected, and on the macro- and microclimatic conditions. Many compounds in propolis exert antioxidative activity. A belief was expressed that the biological activity of propolis is very probably based mostly on its antioxidative efficiency. Dalmatian propolis showed high efficiency in the prevention of oxidative processes. This could be explained by the high proportion of polyphenol constituents, especially flavonoids. A very low and equal degree of increase of PN, as a measure of oxidative processes, was noticed in the samples of triglyceride substrate with the addition of propolis and (+)-catechin. The greatest rise of TBARS was measured in the samples of pure lard. There was no increase of TBARS only in the samples with added propolis. Propolis and (+)-catechin showed great efficiency in the inhibition of DPPH-radical, greater than BHT and BHA, which are widely used in food industry.

CONCLUSION: The results indicate that Dalmatian propolis could be an efficient protective agent against oxidative processes in food. The high antioxidative activity of propolis, its natural origin, and present knowledge about its biological properties, make it a very promising nutritional additive for human diet.

Oxidant/antioxidant properties of Croatian native propolis

Sobočanec S, Šverko V, Balog T, Šaric A, Rusak G, Likić S, Kušić B, Katalinić V, Radić S, Marotti T.

Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb.

Native propolis was defined as propolis powder collected from the continental part of Croatia and prepared according to a patented process that preserves all the propolis natural nutritional and organoleptic qualities.

Nine phenolic compounds (out of thirteen tested) in propolis sample were detected by high performance liquid chromatography (HPLC) analysis. Among them chrysin was the most abundant (2478.5 microg/g propolis). Contrary to moderate antioxidant activity of propolis examined in vitro (ferric reduction antioxidant power; FRAP-assay), propolis as a food supplement modulated antioxidant enzymes (AOE) and significantly decreased lipid peroxidation processes (LPO) in plasma, liver, lungs, and brain of mice. The effect was dose- and tissue-dependent. The lower dose (100 mg/kg bw) protected plasma from oxidation, whereas the higher dose (300 mg/kg bw) was pro-oxidative. Hyperoxia (long-term normobaric 100% oxygen) increased LPO in all three organs tested.

The highest vulnerability to oxidative stress was observed in lungs where hyperoxia was not associated with augmentation of AOE. Propolis protected lungs from hyperoxia by increased catalase (CAT) activity. This is of special importance for lungs since lungs of adult animals are highly vulnerable to oxidative stress because of their inability to augment AOE activity. Because of its strong antioxidant and scavenging abilities, native propolis might be used as a strong plant-based antioxidant effective not only in physiological conditions but also in cases that require prolonged high concentration of oxygen.